Here are a few options for a news article title based on the scientific title, keeping it under 13 words and suitable for a news format:

Option 1 (Focus on benefit):

New Light Probes Help Surgeons See Tumors More Clearly

Option 2 (More technical, but concise):

Enzyme ‘Smart’ Probes Light Up Tumors for Better Cancer Surgery

Option 3 (Focus on the mechanism in simpler terms):

‘Smart’ Light Probes Use Enzymes to Highlight Tumors in Surgery

Option 4 (Shortest and most impactful):

New ‘Smart’ Light Probes Aid Precise Tumor Surgery

All of these options are under 13 words and convey the main idea of the scientific paper in a news-oriented style. Option 1 is perhaps the most broadly accessible. Option 4 is the most concise. Let’s go with Option 1 for broader appeal.

Final Answer:

New Light Probes Help Surgeons See Tumors More Clearly

Researchers have engineered a new class of optical contrast agents designed to improve the precision of fluorescence-guided surgery, particularly for cancer. These agents are activated by proteases, enzymes often found at elevated levels in tumor environments, allowing for selective targeting of cancerous tissue. The innovation lies in the agents’ “latent lysosomotropic effect,” meaning they are designed to accumulate within lysosomes, cellular compartments within tumor cells. This accumulation enhances the fluorescent signal specifically at the tumor site, potentially providing surgeons with a clearer and more detailed view of tumor margins during surgery. Traditional contrast agents can sometimes lack specificity or sufficient accumulation in tumors, hindering precise tumor removal. This new approach aims to overcome these limitations by creating agents that are not only activated by tumor-associated proteases but also become trapped within tumor cells, leading to brighter and more specific fluorescence, ultimately assisting surgeons in distinguishing between cancerous and healthy tissue with greater accuracy. The development holds promise for improving surgical outcomes and potentially reducing cancer recurrence by ensuring more complete tumor resection.

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